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208 results

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Page 1
Showing results for myc and poisoning
Search for myca and Poisoning instead (1 results)
FOXA1 regulates alternative splicing in prostate cancer.
Del Giudice M, Foster JG, Peirone S, Rissone A, Caizzi L, Gaudino F, Parlato C, Anselmi F, Arkell R, Guarrera S, Oliviero S, Basso G, Rajan P, Cereda M. Del Giudice M, et al. Cell Rep. 2022 Sep 27;40(13):111404. doi: 10.1016/j.celrep.2022.111404. Cell Rep. 2022. PMID: 36170835 Free PMC article.
Dysregulation of alternative splicing in prostate cancer is linked to transcriptional programs activated by AR, ERG, FOXA1, and MYC. Here, we show that FOXA1 functions as the primary orchestrator of alternative splicing dysregulation across 500 primary and metastatic prost …
Dysregulation of alternative splicing in prostate cancer is linked to transcriptional programs activated by AR, ERG, FOXA1, and MYC. …
In vivo screening identifies SPP2, a secreted factor that negatively regulates liver regeneration.
Lin YH, Zeng Q, Jia Y, Wang Z, Li L, Hsieh MH, Cheng Q, Pagani CA, Livingston N, Lee J, Zhang Y, Sharma T, Siegwart DJ, Yimlamai D, Levi B, Zhu H. Lin YH, et al. Hepatology. 2023 Oct 1;78(4):1133-1148. doi: 10.1097/HEP.0000000000000402. Epub 2023 Apr 12. Hepatology. 2023. PMID: 37039560
APPROACH AND RESULTS: To enrich for secreted factors that regulate growth control, we induced massive liver overgrowth with either YAP or MYC . Differentially expressed secreted factors were identified in these livers using transcriptomic analysis. ...Spp2 -deficient mice …
APPROACH AND RESULTS: To enrich for secreted factors that regulate growth control, we induced massive liver overgrowth with either YAP or …
Expression of myc-family, myc-interacting, and myc-target genes during preimplantation mouse development.
Domashenko AD, Latham KE, Hatton KS. Domashenko AD, et al. Mol Reprod Dev. 1997 May;47(1):57-65. doi: 10.1002/(SICI)1098-2795(199705)47:1<57::AID-MRD8>3.0.CO;2-P. Mol Reprod Dev. 1997. PMID: 9110315
Other studies revealed that preimplantation embryos lacking c-myc, N-myc, or L-myc are viable, indicating that these genes are either not essential for preimplantation development or can be substituted for functionally by other myc gene family members. …
Other studies revealed that preimplantation embryos lacking c-myc, N-myc, or L-myc are viable, indicating that these ge …
MYC prevents apoptosis and enhances endoreduplication induced by paclitaxel.
Gatti G, Maresca G, Natoli M, Florenzano F, Nicolin A, Felsani A, D'Agnano I. Gatti G, et al. PLoS One. 2009;4(5):e5442. doi: 10.1371/journal.pone.0005442. Epub 2009 May 6. PLoS One. 2009. PMID: 19421315 Free PMC article.
BACKGROUND: The role of the MYC oncogene in the apoptotic pathways is not fully understood. ...We used the microtubules damaging agent paclitaxel (PTX), to arrest the cells in the M phase, in a p53 mutated melanoma cell line with modulated Myc level and activity. An …
BACKGROUND: The role of the MYC oncogene in the apoptotic pathways is not fully understood. ...We used the microtubules damaging agen …
Toward elucidation of dioxin-mediated chloracne and Ah receptor functions.
Bock KW. Bock KW. Biochem Pharmacol. 2016 Jul 15;112:1-5. doi: 10.1016/j.bcp.2016.01.010. Epub 2016 Jan 23. Biochem Pharmacol. 2016. PMID: 26801687 Review.
AhR operates in cooperation with other transcription factors including c-Myc, Blimp1 and ss-Catenin/TCF: c-Myc stimulates exit of stem cells from quiescence to proliferating sebocyte progenitors; Blimp1 is a major c-Myc repressor, and ss-Catenin/TCF represses …
AhR operates in cooperation with other transcription factors including c-Myc, Blimp1 and ss-Catenin/TCF: c-Myc stimulates exit …
C-myc overexpression and p53 loss cooperate to promote genomic instability.
Yin XY, Grove L, Datta NS, Long MW, Prochownik EV. Yin XY, et al. Oncogene. 1999 Feb 4;18(5):1177-84. doi: 10.1038/sj.onc.1202410. Oncogene. 1999. PMID: 10022123
This is not seen with either N-myc or L-myc. Tetraploidy is accompanied by significantly higher levels of cyclin B and its associated cdc2 kinase activity. Mitotic spindle poisons accelerate the appearance of tetraploidy in cells either lacking functional p53 …
This is not seen with either N-myc or L-myc. Tetraploidy is accompanied by significantly higher levels of cyclin B and its ass …
Myeloid-Mas Signaling Modulates Pathogenic Crosstalk among MYC(+)CD63(+) Endothelial Cells, MMP12(+) Macrophages, and Monocytes in Acetaminophen-Induced Liver Injury.
Chen S, Lu Z, Zhao Y, Xia L, Liu C, Zuo S, Jin M, Jia H, Li S, Zhang S, Yang B, Wang Z, Li J, Wang F, Yang C. Chen S, et al. Adv Sci (Weinh). 2024 Apr;11(16):e2306066. doi: 10.1002/advs.202306066. Epub 2024 Feb 13. Adv Sci (Weinh). 2024. PMID: 38350725 Free PMC article.
The characteristic landscape of mouse AILI models involves reciprocal cellular communication among MYC(+)CD63(+) endothelial cells, MMP12(+) macrophages, and monocytes, which is maintained by enhanced glycolysis and the NF-kappaB/TNF-alpha signaling pathway due to myeloid- …
The characteristic landscape of mouse AILI models involves reciprocal cellular communication among MYC(+)CD63(+) endothelial cells, M …
A first-in-class clinical G-quadruplex-targeting drug. The bench-to-bedside translation of the fluoroquinolone QQ58 to CX-5461 (Pidnarulex).
Xu H, Hurley LH. Xu H, et al. Bioorg Med Chem Lett. 2022 Dec 1;77:129016. doi: 10.1016/j.bmcl.2022.129016. Epub 2022 Oct 3. Bioorg Med Chem Lett. 2022. PMID: 36195286 Review.
CX-3543 (Quarfloxin) and CX-5461 (Pidnarulex) were originally derived from a group of fluoroquinolones that were shown to have dual topoisomerase II (Top2) and G-quadruplex (G4) interactions, and QQ58 was the starting structure for their design. Quarfloxin was initially shown to …
CX-3543 (Quarfloxin) and CX-5461 (Pidnarulex) were originally derived from a group of fluoroquinolones that were shown to have dual topoisom …
Aflatoxin B(1) induces S phase arrest by upregulating the expression of p21 via MYC, PLK1 and PLD1.
Huang B, Mu P, Chen X, Tang S, Ye W, Zhu W, Deng Y. Huang B, et al. Biochem Pharmacol. 2019 Aug;166:108-119. doi: 10.1016/j.bcp.2019.05.008. Epub 2019 May 7. Biochem Pharmacol. 2019. PMID: 31075264
Consistently, p21 was upregulated, and PLK1, MYC and PLD1 were downregulated in mouse kidney after AFB(1) treatment. Interestingly, AFB(1) also decreased the physical interaction between PLK1 and MYC and weakened the stability of the MYC protein. Importantly, …
Consistently, p21 was upregulated, and PLK1, MYC and PLD1 were downregulated in mouse kidney after AFB(1) treatment. Interestingly, A …
c-myc in whitefish (Coregonus lavaretus): structure, expression, and insights into possible posttranscriptional regulatory mechanism.
Brzuzan P, Kramer C, Łakomiak A, Jakimiuk E, Florczyk M, Woźny M. Brzuzan P, et al. Fish Physiol Biochem. 2015 Oct;41(5):1155-71. doi: 10.1007/s10695-015-0077-2. Epub 2015 May 21. Fish Physiol Biochem. 2015. PMID: 25995172
Despite the important role of c-myc in mediating the biological effects, studies of c-myc gene expression and factors that control it in organisms other than mammals, such as fish, have been rare. ...We were particularly interested in whether miRNA-34, a known negat …
Despite the important role of c-myc in mediating the biological effects, studies of c-myc gene expression and factors that con …
208 results